Toxic and antifertility effects of quinacrine hydrochloride in rats.

A single instillation of an aqueous suspension containing 40 mg. of quinacrine hydrochloride into the uterine horns of adult rats prevented implantation for at least 4 weeks. A suboptimal dose of 5 mg. could be potentiated by the addition of epinephrine or metaraminol. In some animals, the use of the quinacrine hydrochloride suspension resulted in atrophy and necrosis of the treated uterine horn, a constriction of the lower colon which blocked the propulsion of intestinal contents, and death.